2010 Fiscal Year Final Research Report
Biochemical analysis of new secreted APP and mutant Aβ
| Project/Area Number |
21680032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | National Institute for Longevity Sciences,NCGG |
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Principal Investigator |
TAKEDA Kazuya 独立行政法人国立長寿医療研究センター, 加齢健康脳科学研究部, 流動研究員 (40393160)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 老化性痴呆疾患 / アルツハイマー病 / アミロイド |
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| Research Abstract |
Deposition of Amyloid beta protein (Aβ) is the hallmark of Alzheimer's disease (AD) brain. Heterogeneity is observed in the N- and C-termini of Aβ species. We have previously reported that N-terminally truncated Aβ, Aβ5-40/42, is deposited in pathological legions of AD brain. To elucidate the mechanisms of generation of and the effect on amyloid formation of Aβ5-40/42, we generated a novel monoclonal antibody specific to C-terminal end of secreted APP (sAPP) and identified a new form of sAPP. In addition, we analyzed biochemical and physical property of mutant Aβ peptides.
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