2011 Fiscal Year Final Research Report
Mechanism underlying the glucocorticoid-decreased function of neurotrophic factor in depression.
| Project/Area Number |
21680034
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
NUMAKAWA Tadahiro 独立行政法人国立精神・神経医療研究センター, 神経研究所疾病研究第3部, 室長 (40425690)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神 / 神経疾患の病態と治療 |
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| Research Abstract |
Following glucocorticoid(stress hormone) exposure, BDNF-dependent synaptic maturation was decreased in cultured cortical neurons. We found that shp2-TrkB interaction, which is important for BDNF-mediated synaptic protein expression, was also reduced. In vivo models, we examined possible change of BDNF-related intracellular signaling in forebrain after restraint stress. We found that significant GR downregulation after restraint operation and confirmed a decrease in BDNF-stimulated neurotransmitter release.
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