2011 Fiscal Year Final Research Report
Molecular mechanism of inhibition of insect odor-gated ion channels
| Project/Area Number |
21680035
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATO Koji 東京大学, 生産技術研究所, 特任講師 (20444101)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 嗅覚 / 味覚 / イオンチャネル / シグナル伝達 |
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| Research Abstract |
Insect olfactory receptors compose heteromeric ion channels activated by odorants. Receptor screening experiments revealed the genes encoding ionotropic receptors. I expressed the receptors in heterologous cells, and analyzed their activity. I found some compounds competed with a ligand at their binding site on receptors. The receptor screening of silk moth genome showed a sugar-regulated ion channel, in which structurally related sugar inhibited its binding site. Finally, mutagenesis experiment of olfactory receptor complex identified the amino acid residue contributing the function of channel pore formation.
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[Journal Article] Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT12010
Author(s)
Iwabu M, Yamauchi T, Okada-Iwabu M, Sato K, Nakagawa T, Funata M, Yamaguchi M, Namiki S, Nakayama R, Tabata M, Ogata H, Kubota N, Takamoto I, Hayashi YK, Yamauchi N, Waki H, Fukayama M, Nishino I, Tokuyama K, Ueki K, Oike Y, Ishii S, Hirose K, Shimizu T,
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Journal Title
Nature
Volume: 464
Pages: 1313-1319
DOI
Peer Reviewed
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