2011 Fiscal Year Final Research Report
Integration of motor and reward information in direct and indirect pathways of basal ganglia
| Project/Area Number |
21680036
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tamagawa University (2010-2011)
The Institute of Physical and Chemical Research (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経科学 / 脳・神経 / 生理学 |
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| Research Abstract |
The goal of our study is to elucidate the cellular mechanism of an integration of motor information and reward information in rat striatum. We performed a juxtacellular recording from single striatal neurons which were later stained for dopamine D1 receptors, and a multi-unit recording from many neurons in the motor cortex during forelimb movements. The striatal neurons showed motor-related activity that was positively modulated by reward information irrespective of the expression of D1 receptors. In contrast, only a few neurons showed such modulation in the motor cortex. These results suggest that the expression of dopamine D1 receptors does not determine the integration of motor and reward information in the motor cortex-basal ganglia loop.
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