2012 Fiscal Year Final Research Report
Development of novel rat models for epilepsy and their molecular pathologic analysis
| Project/Area Number |
21680037
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Kyoto University |
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Principal Investigator |
MASHIMO Tomoji 京都大学, 大学院・医学研究科, 特定准教授 (80397554)
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| Project Period (FY) |
2009 – 2012
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| Keywords | てんかん / ラット / 疾患モデル / ENU ミュータジェネシス / 遺伝子 |
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| Research Abstract |
By phenotype-driven ENU mutagenesis approach, we identified a S309T missense mutation in voltage-gated potassium channel, Kcna1 gene, which was the causative gene of human Episodic ataxia type1 (EA1). We have also identified a missense mutation in the gene associated with the oxidant stress as an epileptic rat model. By gene-driven ENU mutagenesis, we have generated Lgi1mutant (L385R) rats as a rat model for the human autosomal dominant lateral temporal lobe epilepsy (ADLTE). These epileptic rats are freely available from the National Bio-Resource Project for the rat in Japan.
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[Journal Article] Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures2012
Author(s)
Ishida S, Sakamoto Y, Nishio T, Baulac S, Kuwamura M, Ohno Y, Takizawa A, Kaneko S, Serikawa T, *Mashimo T
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Journal Title
Brain Research
Volume: 1435
Pages: 154-66
DOI
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[Journal Article] A rat model for Lgi1-related epilepsies2012
Author(s)
*Baulac S, Ishida S, *Mashimo T, Boillot M, Fumoto N, Kuwa mura M, Ohno Y, Takizawa A, Aoto T, Ueda M, Ikeda A, Leguern E, Takahashi R, Serikawa T
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Journal Title
Hum Mol Genet
Volume: 21(16)
Pages: 3546-57
DOI
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[Journal Article] A missense mutation of the gene encoding voltage-dependent sodium channel Nav1.1 confers susceptibility to febrile seizures in rats.2010
Author(s)
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, Serikawa T.
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Journal Title
J Neuroscience
Volume: 30(16):
Pages: 5744-5753
DOI
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