2011 Fiscal Year Final Research Report
Preparation of bone-specific polymer biomaterials
| Project/Area Number |
21680043
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kansai University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | ポリリン酸エステル / ミネラリゼーション / 有機触媒 / 生体適合性 / 生分解性 / 開環重合 / 骨粗鬆症 / 骨転移 |
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| Research Abstract |
In order to prepare bone specific polymer biomaterials, we have synthesized polyphosphoester ionomers and compared their fundamental actions with bisphosphonates. The adsorption amount of polyphosphoester ionomers on hydroxy apatite(HAp) microparticles was increased with an increase in the ionized units in polyphosphoesters and the affinity of ionomers for HAp microparticles was enhanced by formation of sodium salt. Polyphosphoesters ionomers could significantly reduce HAp-formation compared with pamidronate. Moreover, the resorption of HAp was also reduced with addition of polyphosphoester ionomers as a similar to pamidronate. The cytotoxicity of polyphosphoester ionomers was significantly lower than that of pamidronate and cell compatibility of the ionomer further improved by sodium salt formation of the polyphosphoester ionomers. Furthermore, the increment in ALP activity and mineral deposition of mouse osteoblast cells in contact with ionomers was observed.
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