2011 Fiscal Year Final Research Report
Genome-wide association studies in world class athletes
| Project/Area Number |
21680050
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
FUKU Noriyuki 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (40392526)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ゲノムワイド関連解析 / 遺伝子多型 / ミトコンドリア / 核 / アスリート / ケニア / ジャマイカ / アメリカ / 日本 |
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| Research Abstract |
The present study was to identify genetic polymorphisms which were associated with elite sprint/power and/or endurance athlete status in world class athletes of Kenya, Jamaica, US, and Japan. We found that mitochondrial haplogroups were associated with elite endurance athlete status in elite Kenyan and Japanese athletes, also found intriguing associations between mitochondrial haplogroups with sprint/power athlete status in elite Japanese and African-American athletes, and with muscle power in Japanese non-athlete individuals. A genome-wide association studies(GWAS) was performed in elite sprint/power and endurance athletes of Jamaican and Japanese. In Japanese athletes, frequencies of each polymorphism between sprint/power and endurance athletes were compared using Chi-square tests. Among 750, 000 genetic polymorphisms, 5 allele frequencies differed significantly(p<0.00001) between groups.
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[Journal Article] Importance of mitochondrial haplotypes and maternal lineage in sprint performance among individuals of West African ancestry2012
Author(s)
Deason M, Scott R, Irwin L, Macaulay V, Fuku N, Tanaka M, Irving R, Charlton V, Morrison E, Austin K, Pitsiladis YP
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Journal Title
Scand J Med Sci Sports
Volume: 22(2)
Pages: 217-23
DOI
Peer Reviewed
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[Journal Article] FTO genotype and adiposity in children : physical activity levels influence the effect of the risk genotype in adolescent males2010
Author(s)
Scott RA, Bailey ME, Moran CN, Wilson RH, Fuku N, Tanaka M, Tsiokanos A, Jamurtas AZ, Grammatikaki E, Moschonis G, Manios Y, Pitsiladis YP
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Journal Title
Eur J Hum Genet
Volume: 18(12)
Pages: 1339-43
DOI
Peer Reviewed
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[Presentation] Analysis of multiple performance-associated genetic polymorphisms in elite Jamaican sprinters2010
Author(s)
Noriyuki Fuku, Michael Deason, Guan Wang, Robert A Scott, Eri Mikami, Laura Irwin, Rachael R Irving, Vilma Charlton, Errol Y St A Morrison, Masashi Tanaka, Yannis P Pitsiladis
Organizer
BASES Annual Conference
Place of Presentation
Glasgow
Year and Date
20100906-08
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[Presentation] Analysis of multiple performance-associated genetic polymorphisms in sprint and endurance running world record Holders2010
Author(s)
Noriyuki Fuku, Robert A Scott, Eri Mikami, Guan Wang, Michiel Deason, Laura Irwin, Rachael R Irving, Vilma Charlton, Errol Y St A Morrison, Krista Austin, Dawn Tladi, Samuel Headley, Fred D Kolkhhorst, Bezabih Wolde, Mike Boit, Vinent Onywera, Yoshiji Yamada, Masashi Tanaka, Yannis P Pitsiladis
Organizer
The American College of Sports Medicine 57th Annual Meeting
Place of Presentation
Baltimore
Year and Date
20100531-0604
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