2011 Fiscal Year Final Research Report
A nalys i s of biological effect o f clustered DNA damage induced by X-ray microbeam
| Project/Area Number |
21681006
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Central Research Institute of Electric Power Industry |
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Principal Investigator |
TOMITA Masanori (財)電力中央研究所, 原子力技術研究所, 主任研究員 (00360595)
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| Project Period (FY) |
2009 – 2011
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| Keywords | クラスターDNA損傷 / マイクロビーム / X線 / 放射線影響 / バイスタンダー応答 |
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| Research Abstract |
DNA single-strand break(SSB) repair proteins were localized in the irradiated region of the cells with low doses of X-ray microbeam. W hen the irradiated doses became higher, DNA double-strand break(DSB) repair proteins were localized in the irradiate d region instead of SSB repair proteins. Repair efficiency of DSBs did not depend on the energy of X-ray. In addition, X-ray-induced bystander response depended on the tumor suppressor p53 status.
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