2011 Fiscal Year Final Research Report
Development and Application of Cyanofunctionalization Reactions across Unsaturated Bonds
| Project/Area Number |
21685023
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Organic industrial materials
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKAO Yoshiaki 京都大学, 大学院・工学研究科, 講師 (60346088)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 遷移金属 / 不飽和化合物 / シアノ官能基化反応 |
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| Research Abstract |
The cooperative catalysis by palladium and triphenylborane effects the intramolecular oxycyanation and aminocyanation of alkenes through the cleavage of O-CN bonds and the subsequent insertion of double bonds. The use of 4, 5-bis(diphenylphosphino)-9, 9dimethylxanthene(Xantphos) as a ligand for palladium is essential for allowing the transformation to proceed with high chemo and regioselectivity. Variously substituted dihydrobenzofurans with both a tetrasubstituted carbon and cyano functionality, which are often found in biologically active substances including some pharmaceuticals, are accessed by the newly developed methodology in a highly efficient manner.
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