2011 Fiscal Year Final Research Report

Research and development of biological information platform for ChIP-seq analysis using next generation sequencer

Research Project

Project/Area Number	21687001
Research Category	Grant-in-Aid for Young Scientists (A)
Allocation Type	Single-year Grants
Research Field	Genetics/Genome dynamics
Research Institution	Tokyo Institute of Technology
Principal Investigator	ITOH Takehiko 東京工業大学, 大学院・生命理工学研究科, 教授 (90501106)
Project Period (FY)	2009 – 2011
Keywords	バイオインフォマティクス / ChIP-seq解析
Research Abstract	We developed a new algorithm for ChIP-seq analysis using next generation sequencer(i. e. Solexa/SOLiD) and targeted genome information, which can be picked up protein binding sites cyclopaedically and quantitatively from the entire genome.

[Journal Article] Replisome stability at defective DNA replication forks is independent of S phase checkpoint kinases2012
- Author(s)
  De Piccoli G, Katou Y, Itoh T, et al
- Journal Title
  
  Mol Cell
  
  Volume: 45(5) Pages: 696-704
- Peer Reviewed
[Journal Article] Chromosome length influences replication-induced topological stress Nature2011
- Author(s)
  A. Kegel, H. B. Lindroos, T. Kanno, K. Jeppsson, L. Strom, Y. Katou, T. Itoh, K. Shirahige, et al
- Volume
  471(7338)
- Pages
  392-6
- Peer Reviewed
[Journal Article] ATP Hydrolysis Is Required for Relocating Cohesin from Sites Occupied by Its Scc2/4 Loading Complex Curr2011
- Author(s)
  B. Hu, T. Itoh, A. Mishra, Y. Katoh, K-L. Chan, W. Upcher, C. Godlee, M. B. Roig, K. Shirahige, and K. Nasmyth
- Journal Title
  
  Biol
  
  Volume: 21(1) Pages: 12-24
- Peer Reviewed
[Journal Article] Histone and TK0471/TrmBL2 form a novel heterogeneous genome architecture in the hyperthermophilic archaeon Thermococcus kodakarensis2010
- Author(s)
  H. Maruyama, M. Shin, T. Oda, R. Matsumi, R. L. Ohniwa, T. Itoh, K. Shirahige, T. Imanaka, H. Atomi, S. H. Yoshimura, and K. Takeyasu
- Journal Title
  
  Mol Biol Cell
- Peer Reviewed
[Journal Article] A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion EMBO2010
- Author(s)
  A. Kurze, K. A. Michie, S. E. Dixon, A. Mishra, T. Itoh, S. Khalid, L. Strmecki, K. Shirahige, C. H. Hearing, J. Lowe, and K Nasmyth
- Peer Reviewed