2011 Fiscal Year Final Research Report
In vivo imaging analysis for cellular and molecular mechanisms of body axis tuning
| Project/Area Number |
21687004
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | The Institute of Physical and Chemical Research (2011)
The University of Tokyo (2009-2010) |
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Principal Investigator |
KURANAGA Erina 独立行政法人理化学研究所, 組織形成ダイナミクス研究チーム, チームリーダー (90376591)
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| Project Period (FY) |
2009 – 2011
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| Keywords | イメージング / 組織形成 / 細胞死 / 細胞移動 / ショウジョウバエ |
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| Research Abstract |
In Drosophila development, male genitalia performs 360o clockwise rotation as it forms, but L/R axis of genitalia is deformed if the rotation is incompletely stopped. Imaging analysis reveals that full rotation of genitalia is required the two steps movement of collective cells in epithelial sheet surrounding genitalia. We found that the secondary rotation that was initiated by apoptosis accelerated the primary rotation to adjust the speed of morphogenesis for the developmental time window.
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