2011 Fiscal Year Final Research Report
Understanding epithelial dynamic homeostasis by cell competition
| Project/Area Number |
21687019
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
IGAKI Tatsushi 神戸大学, 大学院・医学研究科, 特命准教授 (00467648)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 細胞競合 / 細胞間コミュニケーション / 癌 / ショウジョウバエ |
|---|
| Research Abstract |
Most cancers arise from a single cell of origin in an epithelial sheet. Therefore, a newly emerged oncogenic cell in the epithelium has to confront anti-tumor selective pressures in the host tissue. However, the mechanisms by which surrounding normal tissue exerts anti-tumor effects against oncogenically transformed cells are poorly understood. Using the Drosophila genetics, we found that normal epithelial cells activate JNK-dependent engulfment pathway in response to the emergence of oncogenic polarity-deficient cells, thereby eliminating oncogenic neighbors through cell competition.
|
