2010 Fiscal Year Final Research Report
Establishment of the systems that regulate the activity of tumor-related factors for tumor suppression
| Project/Area Number |
21688008
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Nihon University |
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Principal Investigator |
MASUHIRO Yoshikazu Nihon University, 生物資源科学部, 講師 (00336083)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞膜透過性タグ / サイトカイ / SOCS / DP-1 / p53 / Stabilon |
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| Research Abstract |
We discovered the newly molecular mechanisms of tumor-related factors. We also established that the expression system of cell-permeable tumor suppressors for the protein therapy of tumor suppression.
(1) Identification of "Stabilon" motif that is significant for protein stability of transcription factor DP-1 concerned with tumor growth.
(2) Discovery of the suppression of TRIP6-mediated LPA signal transduction by SOCS7 and new isoforms of TRIP6.
(3) Establishment of E. coli. expression system of cell-permeable RARa, SOCS-3, p53 and SOCS-2.
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