2011 Fiscal Year Final Research Report
Fundamental research for development of new therapy for canine lymphoma
| Project/Area Number |
21688022
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 犬 / リンパ腫 / 新規治療法 |
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| Research Abstract |
Using hybridoma library established from rat immunized with canine lymphoma cell line, canine PSGL-1 was found to be expressed on normal lymphocytes, but was specifically glycosylated in lymphoma cell line. This indicated that specifically glycosylated canine PSGL-1 molecule could be a target for antibody therapy. On the other hands, Flavopiridol, known as pan-CDK inhibitor, inhibited growth of eight lymphoma cell lines in vitro by regulation of cell cycle, as well as downregulation of anti-apoptotic proteins. Furthermore, we identified the genes specifically expressed in canine lymphoma, which could be a candidate for molecular target therapy in canine lymphoma.
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