2011 Fiscal Year Final Research Report
Development of new cycloaddition reactions with 1, 4-zwitterionic intermediates and application to synthesis of bioactive compounds
| Project/Area Number |
21689001
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 有機合成反応 / 環化付加 / 小員環化合物 / 全合成 |
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| Research Abstract |
We found that formal[ 4+2] cycloaddition reactions of 3-ethoxycyclobutanones with allylsilanes, silyl enol ethers, imines, or indoles proceeded smoothly to afford the corresponding six-membered cyclic compounds in high yields by activating the cyclobutanones with appropriate Lewis acids. We accomplished total synthesis of(±)-bremazocine and(±)-aspidospermidine by using the new cycloaddition.
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Research Products
(17 results)
