2011 Fiscal Year Final Research Report
Evaluation on EPR effect and active control of EPR effect for achieving efficient tumor accumulation of nanocarrier delivery system
| Project/Area Number |
21689002
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | The University of Tokushima |
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Principal Investigator |
ISHIDA Tatsuhiro 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (50325271)
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| Co-Investigator(Renkei-kenkyūsha) |
KIWADA Hiroshi 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (50120184)
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| Project Period (FY) |
2009 – 2011
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| Keywords | DDS / ナノキャリア / 腫瘍 / EPR効果 |
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| Research Abstract |
Chemotherapy delivered in nanocarriers has been developed to improve the clinical treatment of solid tumors by achieving high accumulation of chemotherapeutic agents in tumor tissues but limited accumulation in healthy organs via due to the so-called" enhanced permeability and retention(EPR) effect". We showed that low dose metronomic chemotherapy given the damage in endothelial cells of growing tumor vasculature and tumor cells, increased tumor accumulation of nanocarriers as a result of vascular normalization and enlargement of intratumoral space in solid tumors. This strategy may be breakthrough in anti-cancer chemotherapy with nanocarrier-based anticancer drugs against intractable tumors which have lower vascular density and permeability.
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[Journal Article] Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model : Synergy or antagonism?2012
Author(s)
Abu Lila, A. S., Okada, T., Doi, Y., Ichihara, M., Ishida, T., Kiwada, H.
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Journal Title
Int. J. Pharm.
Volume: 426
Pages: 263-270
Peer Reviewed
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[Journal Article] Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model2012
Author(s)
Tagami, T., Abu Lila, A. S., Matsunaga, M., Moriyoshi, N., Nakamura, H., Nakamura, K., Suzuki, T., Doi, Y., Ishida, T., Kiwada, H.
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Journal Title
Drug Deliv. Transl. Res.
Volume: 2
Pages: 77-86
Peer Reviewed
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[Journal Article] A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA2011
Author(s)
Nakamura, K, Abu Lila A., Matsunaga, M., Doi, Y., Ishida, T., Kiwada, H.
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Journal Title
Mol. Ther.
Volume: 19
Pages: 2040-2047
Peer Reviewed
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[Journal Article] Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model2009
Author(s)
Abu Lila, A., Kizuki, S., Doi, Y., Suzuki, T., Ishida, T., Kiwada, H.
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Journal Title
J. Control. Release
Volume: 137
Pages: 8-14
Peer Reviewed
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