2012 Fiscal Year Final Research Report
Reduction mechanism of methylmercury toxicity by protein palmitoylation
| Project/Area Number |
21689005
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
HWANG Gi-wook 東北大学, 大学院・薬学研究科, 講師 (00344680)
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| Project Period (FY) |
2009 – 2012
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| Keywords | トキシコロジー |
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| Research Abstract |
We previously showed that Akr1 is involved in the reduction of methylmercury toxicity in budding yeast. In the present study, we found that the palmitoylation of Meh1 by Akr1 is essential for the protective effect of Meh1 against methylmercury toxicity. We also found that palmitoylation of Meh1 is important for its localization into the vacuolar membrane and its function to reduce methylmercury toxicity as a component of the EGO complex. Furthermore, the EGO complex may be involved in reduction of methylmercury toxicity through suppressing the abnormal vacuoles form caused by methylmercury.
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