2010 Fiscal Year Final Research Report
Functional role of hTERT-RMRP complex in stem cells and tumor initiating cells
| Project/Area Number |
21689012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
MASUTOMI Kenkichi 独立行政法人国立がん研究センター, 研究所, 分野長 (20450570)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 癌 / 幹細胞 / 生化学 |
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| Research Abstract |
Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase catalytic subunit (hTERT) contributes to cell physiology independent of its ability to elongate telomeres. Here we show that hTERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome Cartilage-Hair Hypoplasia. hTERT and RMRP form a distinct ribonucleoprotein complex that exhibits RNA dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer-dependent manner. These observations identify a mammalian RdRP composed of hTERT in complex with RMRP (Nature 2009, Maida et al.).
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[Presentation] Induction of tumor initiating cell behavior of defined genetic composition by a complex composed of nucleostemin, hTERT and BRG12011
Author(s)
Okamoto N, Yasukawa M, Nguyen C, Possemato R, Fukami K, Hahn WC, Masutomi K.
Organizer
Keystone Symposia "Stem Cells, Cancer and Metastasis"(ポスター発表)
Place of Presentation
Keystone Resort, Keystone, Colorado
Year and Date
20110306-20110311
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