2011 Fiscal Year Final Research Report
Revaluation of contraction band necrosis as a marker for cardiac sudden death
| Project/Area Number |
21689020
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHINTANI Kaori (ISHIDA Kaori) 東京大学, 大学院・医学系研究科, 講師 (50345047)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 心臓突然死 / 収縮帯壊死 / 小胞体 / ミトコンドリア / カルシウム / フォスフォランバン / 心筋梗塞 |
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| Research Abstract |
Contraction bands(CBs) are formed in early phase of myocardial infarction and have been believed to cause myocardial infarction. In rat model of coronary occlusion, the causality of CB for myocardial infarction was investigated. In ischemia-reperfusion, phospholanban(PLN), a regulatory protein of SR calcium uptake, was dephosphorylated, thereby causing formation of CBs. In vivo injection of anti-PLN antibody enhanced SR calcium uptake and inhibited the CB formation. On the other hand, the antibody induced mPTP opening through mitochondrial calcium overload and enlarged the region of myocardial infarction. These results indicate that mPTP opening, but not CB formation, is pivotal for the development of myocardial infarction.
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