2011 Fiscal Year Final Research Report
Pathophysiologic role of saturated fatty acids in the metabolic syndrome
| Project/Area Number |
21689026
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUGANAMI Takayoshi 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教授 (50343752)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 肥満 / 脂肪組織 / マクロファージ / 慢性炎症 / 飽和脂肪酸 |
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| Research Abstract |
Overproduction of saturated fatty acids is considered to be a molecular basis of the metabolic syndrome. In this study, we focused on the intimate crosstalk between adipocytes and macrophages in obese adipose tissue and identified ATF3, an anti-inflammatory transcriptionfactor, and Mincle, a pathogen sensor for mycobacterium tuberculosis, as novel regulators of adipose tissue inflammation. Thus, saturated fatty acids, which are released abundantly from hypertrophied adipocytes in obesity, may induce inflammatory changes in adipose tissue as well as lipotoxicity in remote organs such as liver and skeletal muscle.
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[Journal Article] Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia2012
Author(s)
N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H.Nakaoka, A. Himeno, M. Tochiya, S. Kono, T. Takaya, K. Ono, H. Wada, T. Suganami, K. Hasegawa, Y. Ogawa
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Journal Title
Diabetes Care
Volume: 35
Pages: 2631- 2639
DOI
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[Journal Article] Increased expression of macrophage- inducible C-type lectin in adipose tissue of obese mice and humans2011
Author(s)
M. Ichioka, T. Suganami, N. Tsuda, I.Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa
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Journal Title
Diabetes
Volume: 60
Pages: 819-826
DOI
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[Journal Article] Role of transient receptor potential vanilloid2 in LPS-induced cytokine production in macrophages2010
Author(s)
K. Yamashiro, T. Sasano, K. Tojo, I.Namekata, J. Kurokawa, N. Sawada, T. Suganami, Y. Kamei, H. Tanaka, N. Tajima, K. Utsunomiya, Y. Ogawa, T. Furukawa
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 398
Pages: 284-289
DOI
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[Journal Article] Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue2009
Author(s)
T. Suganami, X. Yuan, Y. Shimoda, K.Uchio-Yamada, N. Nakagawa, I. Shirakawa, T. Usami, T. Tsukahara, K. Nakayama, Y.Miyamoto, K. Yasuda, J. Matsuda, Y. Kamei, S. Kitajima, Y. Ogawa
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Journal Title
Circ. Res
Volume: 105
Pages: 25-32
DOI
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