• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2011 Fiscal Year Final Research Report

Pathophysiologic role of saturated fatty acids in the metabolic syndrome

Research Project

  • PDF
Project/Area Number 21689026
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Endocrinology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUGANAMI Takayoshi  東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教授 (50343752)

Project Period (FY) 2009 – 2011
Keywords肥満 / 脂肪組織 / マクロファージ / 慢性炎症 / 飽和脂肪酸
Research Abstract

Overproduction of saturated fatty acids is considered to be a molecular basis of the metabolic syndrome. In this study, we focused on the intimate crosstalk between adipocytes and macrophages in obese adipose tissue and identified ATF3, an anti-inflammatory transcriptionfactor, and Mincle, a pathogen sensor for mycobacterium tuberculosis, as novel regulators of adipose tissue inflammation. Thus, saturated fatty acids, which are released abundantly from hypertrophied adipocytes in obesity, may induce inflammatory changes in adipose tissue as well as lipotoxicity in remote organs such as liver and skeletal muscle.

  • Research Products

    (20 results)

All 2012 2011 2010 2009 Other

All Journal Article (10 results) Presentation (8 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Highly purified eicosapentaenoic acid increases interleukin-10 levels of peripheral blood monocytes in obese patients with dyslipidemia2012

    • Author(s)
      N. Satoh-Asahara, A. Shimatsu, Y. Sasaki, H.Nakaoka, A. Himeno, M. Tochiya, S. Kono, T. Takaya, K. Ono, H. Wada, T. Suganami, K. Hasegawa, Y. Ogawa
    • Journal Title

      Diabetes Care

      Volume: 35 Pages: 2631- 2639

    • DOI

      doi:10.2337/dc12-0269

  • [Journal Article] Adipose tissue inflammation and ectopic lipid accumulation2012

    • Author(s)
      T. Suganami, M. Tanaka, Y. Ogawa
    • Journal Title

      Endocr. J

      Volume: 59 Pages: 849-857

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22878669

  • [Journal Article] Increased expression of macrophage- inducible C-type lectin in adipose tissue of obese mice and humans2011

    • Author(s)
      M. Ichioka, T. Suganami, N. Tsuda, I.Shirakawa, Y. Hirata, N. Satoh-Asahara, Y. Shimoda, M. Tanaka, M. Kim-Saijo, Y. Miyamoto, Y. Kamei, M. Sata, Y. Ogawa
    • Journal Title

      Diabetes

      Volume: 60 Pages: 819-826

    • DOI

      doi:10.2337/db10-0864

  • [Journal Article] Melanocortin-4 receptor-deficient mice as a novel mouse model of non-alcoholic steatohepatitis2011

    • Author(s)
      M. Itoh, T. Suganami, N. Nakagawa, M.Tanaka, Y. Yamamoto, Y. Kamei, S. Terai, I. Sakaida, Y. Ogawa
    • Journal Title

      Am. J. Pathol

      Volume: 179 Pages: 2454-2463

    • DOI

      doi:10.4061/2011/720926

  • [Journal Article] Adipose tissue macrophages: their role in adipose tissue remodeling2010

    • Author(s)
      T. Suganami, Y. Ogawa
    • Journal Title

      J. Leukoc. Biol

      Volume: 88 Pages: 33-39

    • DOI

      doi:10.1189/jlb.0210072

  • [Journal Article] Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: effect of pioglitazone2010

    • Author(s)
      N. Satoh, A. Shimatsu, A. Himeno, Y. Sasaki, H. Yamakage, K. Yamada, T. Suganami, Y.Ogawa
    • Journal Title

      Diabetes Care

      Volume: 33 Pages: e7

    • DOI

      doi:10.2337/dc09- 1315

  • [Journal Article] Anti-obesity effect ofeicosapentaenoic acid in high-fat/high-sucrose diet-induced obesity: importance of hepatic lipogenesis2010

    • Author(s)
      A. Sato, H. Kawano, T. Notsu, M. Ohta, M.Nakakuki, K. Mizuguchi, M. Itoh, T. Suganami, Y. Ogawa
    • Journal Title

      Diabetes

      Volume: 59 Pages: 2495-2504

    • DOI

      doi:10.2337/db09-1554

  • [Journal Article] Role of transient receptor potential vanilloid2 in LPS-induced cytokine production in macrophages2010

    • Author(s)
      K. Yamashiro, T. Sasano, K. Tojo, I.Namekata, J. Kurokawa, N. Sawada, T. Suganami, Y. Kamei, H. Tanaka, N. Tajima, K. Utsunomiya, Y. Ogawa, T. Furukawa
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 398 Pages: 284-289

    • DOI

      doi:10.1016/j.bbrc.2010.06.082

  • [Journal Article] Insulin-inducedectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro2010

    • Author(s)
      T. Yamamoto, T. Suganami, M. Kiso-Narita, PA. Scherle, Y. Kamei1, M. Isobe, S. Higashiyama, Y. Ogawa
    • Journal Title

      Obesity

      Volume: 18 Pages: 1888-1894

    • DOI

      doi:10.1038/oby.2010.2

  • [Journal Article] Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue2009

    • Author(s)
      T. Suganami, X. Yuan, Y. Shimoda, K.Uchio-Yamada, N. Nakagawa, I. Shirakawa, T. Usami, T. Tsukahara, K. Nakayama, Y.Miyamoto, K. Yasuda, J. Matsuda, Y. Kamei, S. Kitajima, Y. Ogawa
    • Journal Title

      Circ. Res

      Volume: 105 Pages: 25-32

    • DOI

      doi:10.1161/CIRCRESAHA.109. 196261

  • [Presentation] 肥満の脂肪組織における新たな炎症関連遺伝子の探索2012

    • Author(s)
      市岡誠之、菅波孝祥 他
    • Organizer
      第31回日本肥満学会学術大会
    • Place of Presentation
      前橋
    • Year and Date
      20121001-20101002
  • [Presentation] 脂肪組織の慢性炎症と飽和脂肪酸2012

    • Author(s)
      菅波孝祥 他
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      20120705-20120706
  • [Presentation] 脂肪組織炎症における病原体センサーの意義2012

    • Author(s)
      菅波孝祥 他
    • Organizer
      第55回日本糖尿病学会学術集会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      20120517-20120519
  • [Presentation] 脂肪組織炎症における飽和脂肪酸の意義2012

    • Author(s)
      菅波孝祥 他
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      20120419-20120421
  • [Presentation] Obesity and adipose tissue inflammation2011

    • Author(s)
      T. Suganami, et al
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      20111213-20121016
  • [Presentation] Obesity and adipose tissue inflammation2011

    • Author(s)
      T. Suganami, et al
    • Organizer
      第19回日本血管生物医学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      20111208-20121210
  • [Presentation] 肥満の脂肪組織炎症性における脂肪細胞とマクロファージの相互作用2009

    • Author(s)
      菅波孝祥 他
    • Organizer
      第30回日本肥満学会学術大会
    • Place of Presentation
      浜松(招待講演)
    • Year and Date
      20091009-20091010
  • [Presentation] 肥満脂肪組織の炎症性変化における脂肪細胞とマクロファージの相互作用の意義2009

    • Author(s)
      菅波孝祥 他
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      前橋(招待講演)
    • Year and Date
      20090423-20090425
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/grad/cme/index.html

  • [Patent(Industrial Property Rights)] 脂肪細胞の炎症性変化を抑制する物質のスクリーニング系及びそれを用いたスクリーニング方法2011

    • Inventor(s)
      小川佳宏、菅波孝祥
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学
    • Industrial Property Number
      4862160
    • Acquisition Date
      2011-11-18

URL: 

Published: 2014-08-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi