2011 Fiscal Year Final Research Report
Expansion of hematopoietic stem/progenitor cells by suppressing E2A activities
| Project/Area Number |
21689027
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hematology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IKAWA Tomokatsu 独立行政法人理化学研究所, 免疫発生研究チーム, 研究員 (60450392)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 造血幹細胞 / 自己複製 / Id3 / 転写因子 / E2A / B細胞分化 |
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| Research Abstract |
We have developed a novel method for expanding hematopoietic stem/progenitor cells by suppressing E2A activities. This was done by ectopic expression of Id3 into hematopoietic stem cells and cultured the infected cells in a B cell differentiating conditions. The cells have potential to proliferate enormously in vitro and to generate lymphoid and myeloid lineage cells. We named the cells induced Leukocyte Stem(iLS) cells.
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Research Products
(21 results)
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[Journal Article] Notch-Hes1 pathway is required for the development of IL-17-producing gd T cells2011
Author(s)
Shibata K, Yamada H, Sato T, Dejima T, Nakamura M, Ikawa T, Hara H, Yamasaki S, Kageyama R, Iwakura Y, Kawamoto H, Toh H, Yoshikai Y.
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Journal Title
Blood
Volume: 118
Pages: 586-593
Peer Reviewed
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[Journal Article] Aberrant induction of LMO2 theE2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t2010
Author(s)
Hirose K, Inukai T, Kikuchi J, Furukawa Y, Ikawa T, Kawamoto H, Oram SH, Gottgen B, Kiyokawa N, Miyagawa Y, Okita H, Akahane K, Zhang X, Kuroda I, Nonna H, Kagami K, Goi K, Kurosawa H, Look AT, Matsui H, Inaba T and Sugita K.
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Journal Title
Blood
Volume: 116
Pages: 962-970
Peer Reviewed
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[Journal Article] Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT22009
Author(s)
Higashi AY, Ikawa T, Muramatsu M, Ecnomides AN, Niwa A, Okuda T, Murphy AJ, Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, and Yanagita M.
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Journal Title
J. Immunol.
Volume: 182
Pages: 5633-5640
Peer Reviewed
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