2010 Fiscal Year Final Research Report
The identification of invasion associated genes in glioma stem cell
| Project/Area Number |
21689038
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAKADA Mitsutoshi Kanazawa University, 医学系, 助教 (20334774)
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| Project Period (FY) |
2009 – 2010
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| Keywords | グリオーマ / 幹細胞 / 浸潤 / インテグリン |
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| Research Abstract |
Glioma stem-like cells are shown to be invasive but its mechanism remains to be elucidated. In this study we demonstrate the function of integrin in glioma stem-like cell invasion. The expression profile of integrin family in CD133+ and - cells was determined. Integrin α3 was overexpressed in CD133+ cells compared with CD133- cells. Immunohistochemistry demonstrated the localization of integrin alpha3 in invading glioblastoma cells. The activity of glioma cell invasion was associated with the expression level of integrin α3. The migration activity of glioma cell lines was linked to the phosphorylation level of ERK (extracellular signal-regulated kinase) 1/2. Our results suggest that endogenous integrin alpha3 contributes the invasive nature of glioma stem-like cells, which renders integrin alpha3 as a prime candidate for anti-invasion therapy for glioblastoma.
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[Journal Article] Epithelioid glioblastoma changed to typical glioblastoma : the methylation status of MGMT promoter and 5-ALA fluorescence.2011
Author(s)
Tanaka S, Nakada M, Hayashi Y, Nakada S, Kitamura-Sawada S, Furuyama N, Suzuki T, Kamide T, Hayashi Y, Yano S, Hamada JI.
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Journal Title
Brain Tumor Pathol 28
Pages: 59-64
Peer Reviewed
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[Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells.2011
Author(s)
Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu JI, Saya H, Hamada JI, Hirao A.
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Journal Title
Can Res 71
Pages: 1135-1145
Peer Reviewed
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[Journal Article] Secondary anaplastic astrocytoma developing in a young adult with autoimmune lymphoproliferative syndrome (ALPS).2010
Author(s)
Kita D, Hayashi Y, Watanabe T, Korshunov A, von Deimling A, Nakada M, Kinoshita M, Uchiyama N, Kasahara Y, Zen Y, Hamada JI, Hayashi Y.
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Journal Title
Neuropathology and Applied Neurobiology (Epub ahead of print)
Peer Reviewed
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[Journal Article] PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.2010
Author(s)
Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC.
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Journal Title
Genes & Development 24
Pages: 2205-2218
Peer Reviewed
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[Journal Article] Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with survival of patients with glioblastoma.2010
Author(s)
Yoshida Y, Nakada M, Sugimoto N, Harada T, Hayashi Y, Kita D, Uchiyama N, Hayashi Y, Yachie A, Takuwa Y, Hamada JI.
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Journal Title
Int J Cancer 126
Pages: 2341-2352
Peer Reviewed
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[Journal Article] Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.2009
Author(s)
Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A.
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Journal Title
Proc Natl Acad Sci USA 106
Pages: 17163-17168
Peer Reviewed
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