Aging and Regulation of Bone Metabolism

2011 Fiscal Year Final Research Report

• Project/Area Number: 21689040
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Orthopaedic surgery
• Research Institution: Keio University
• Principal Investigator: MIYAMOTO Takeshi 慶應義塾大学, 医学部・総合医科学研究センター, 特任准教授 (70383768)
• Project Period (FY): 2009 – 2011
• Keywords: 骨 / 軟骨代謝学

Research Abstract

We identified that transcriptional repressors namely B lymphocyte maturation protein 1(Blimp1) and B cell lymphoma 6(Bcl6) critically regulate osteoclast differentiation and bone homeostasis(J Exp Med 2010). We also identified that osteoclast stimulatory transmembrane protein(OC-STAMP) is required for osteoclast cell-cell fusion(J Bone Miner Res in press).

Research Products

• [Journal Article] PDGFBB promotes PDGFRα -positive cell migration into artificial bone in vivo (2012)
  • Author(s): Yoshida S, Iwasaki R, Kawana H, Miyauchi Y, Hoshi H, Miyamoto H, Mori T, Kanagawa H, Katsuyama E, Fujie A, Hao W, Kobayashi T, Sato Y, Miyamoto K, Morioka H, Matsumoto M, Chiba K, Toyama Y, Nakagawa T, Miyamoto T
  • Journal Title: Biochem Biophys Res Commun Volume: (in press)
  • Peer Reviewed
• [Journal Article] Clinical Significance of Cartilage Biomarkers for Monitoring Structural Joint Damage in Rheumatoid Arthritis Patients Treated with Anti-TNF Therapy (2012)
  • Author(s): Niki Y, Takeuchi T, Nakayama M, Nagasawa H, Kurasawa T, Yamada H, Toyama Y, Miyamoto T
  • Journal Title: PLoS One Volume: (in press)
  • Peer Reviewed
• [Journal Article] Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis (2012)
  • Author(s): Hoshi H, Hao W, Fujita Y, Funayama A, Miyauchi Y, Hashimoto K, Miyamoto K, Iwasaki R, Sato Y, Kobayashi T, Miyamoto H, Yoshida S, Mori T, Kanagawa H, Katsuyama E, Fujie A, Kitagawa K, Nakayama KI, Kawamoto T, Sano M, Fukuda K, Ohsawa I, Ohta S, Morioka H,Matsumoto M, Chiba K, Toyama Y, Miyamoto T
  • Journal Title: J Bone Miner Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] OC-STAMP and DC-STAMP cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells (2012)
  • Author(s): Miyamoto H, Suzuki T, Miyauchi Y, Iwasaki R, Kobayashi T, Sato Y, Miyamoto K, Hoshi H, Hashimoto K, Yoshida S, Hao W, Mori T, Kanagawa H, Katsuyama E, Fujie A, Morioka H, Matsumoto M, Chiba K, Takeya M, Toyama Y and Miyamoto T
  • Journal Title: J Bone Miner Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Vitamin E decreases bone mass by stimulating osteoclast fusion (2012)
  • Author(s): Fujita K, Iwasaki M, Ochi H, Fukuda T, Ma C, Miyamoto T, Takitani K, Negishi-Koga T, Sunamura S, Kodama T, Takayanagi H, Tamai H, Kato S, Arai H, Shinomiya K, Itoh H, Okawa A, Takeda S
  • Journal Title: Nat Med Volume: 18(4) Pages: 589-594
  • Peer Reviewed
• [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization (2011)
  • Author(s): Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, Yasuda H, Penninger JM, Toyama Y, Suda T and Miyamoto T
  • Journal Title: J Exp Med Volume: 208(11) Pages: 2175-81
  • Peer Reviewed
• [Journal Article] Regulators of Osteoclast Differentiation and Cell-Cell Fusion (2011)
  • Author(s): Miyamoto T
  • Journal Title: Keio J Med Volume: 60(4) Pages: 101-105
  • Peer Reviewed
• [Journal Article] IL-1{beta} and TNF{alpha}-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis (2011)
  • Author(s): Mori T, Miyamoto T, Yoshida H, Asakawa M, Kawasumi M, Kobayashi T, Morioka H, Chiba K, Toyama Y, Yoshimura A
  • Journal Title: Int Immunol Volume: 23(11) Pages: 701-12
  • Peer Reviewed
• [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis (2010)
  • Author(s): Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
  • Journal Title: J Exp Med Volume: vol.207 Pages: 751-762
  • Peer Reviewed
• [Journal Article] Anti-apoptotic Molecule Bcl-2 Regulates the Differentiation, Activation, and Survival of Both Osteoblasts and Osteoclasts (2009)
  • Author(s): Nagase Y, Iwasawa M, Akiyama T, Kadono Y, Nakamura M, Oshima Y, Yasui T, Matsumoto T, Hirose J, Nakamura H, Miyamoto T, Bouillet P, Nakamura K, Tanaka S
  • Journal Title: J Biol Chem Volume: 284(52) Pages: 36659-36669
  • Peer Reviewed
• [Journal Article] 1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression (2009)
  • Author(s): Sakai S, Takaishi H, Matsuzaki K, Kaneko H, Furukawa M, Miyauchi Y, Shiraishi A, Saito K, Tanaka A, Taniguchi T, Suda T, Miyamoto T, Toyama Y
  • Journal Title: J Bone Miner Metab Volume: 27(6) Pages: 643-652
  • Peer Reviewed
• [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner (2009)
  • Author(s): Miyamoto K, Ninomiya K, Sonoda K, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egarashi K, Suda T, Toyama Y, Miyamoto T
  • Journal Title: Biochem Biophys Res Commun Volume: 383 Pages: 373-377
  • Peer Reviewed
• [Presentation] STAT3 is critical to promote inflammatory cytokines and RANKL expression in inflammatory arthritis (2011)
  • Author(s): Miyamoto T, et al
  • Organizer: 1^<st> Bio-Rheumatology International Congress
  • Place of Presentation: Hilton Bay Tokyo, Chiba
  • Year and Date: 20111113-16
• [Presentation] 炎症と破骨細胞制御機構 (2011)
  • Author(s): 宮本健史、森智章、吉村昭彦、戸山芳昭
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
  • Year and Date: 20111020-21
• [Presentation] OC-STAMPは破骨細胞,異物巨細胞の細胞融合に必須である (2011)
  • Author(s): 宮本裕也、森岡秀夫、千葉一裕、戸山芳昭、宮本健史
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
  • Year and Date: 20111020-21
• [Presentation] STAT3は関節リウマチ治療の新たな分子標的である (2011)
  • Author(s): 森智章、宮本健史、吉村昭彦、戸山芳昭
  • Organizer: 第26回日本整形外科学会基礎学術集会
  • Place of Presentation: 前橋
  • Year and Date: 20111020-21
• [Presentation] OC-STAMP and DC-STAMP are both essential for cell-cell fusion in osteoclasts and foreign body giant cells (2011)
  • Author(s): Miyamoto H, Morioka H, Chiba K, Toyama Y and Miyamoto T
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research 2011
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 20110916-20
• [Presentation] STAT3 is a novel target for treating bone resorption in Rheumatoid arthritis (2011)
  • Author(s): Mori T, Toyama Y, Yoshimura A, Miyamoto T
  • Organizer: Annual Meeting of the American Society for Bone and Mineral Research 2011
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 20110916-20
• [Presentation] STAT3は関節リウマチ治療の新たな分子標的である (2011)
  • Author(s): 森智章、宮本健史、吉村昭彦、戸山芳昭
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20110728-30
• [Presentation] 転写抑制因子Blimp1は骨代謝制御の分子標的である (2011)
  • Author(s): 宮内芳輝、戸山芳昭、宮本健史
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20110728-30
• [Presentation] Aldh2遺伝子変異はアセトアルデヒド及び酸化脂質の蓄積により骨芽細胞の分化抑制をきたす (2011)
  • Author(s): 星淡子、呉コウ、戸山芳昭、宮本健史
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20110728-30
• [Presentation] OC-STAMPは破骨細胞、異物巨細胞の細胞融合に必須である (2011)
  • Author(s): 宮本裕也、森岡秀夫、千葉一裕、戸山芳昭、宮本健史
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20110728-30
• [Presentation] Regulation of osteoclast differentiation and cell-cell fusion (2011)
  • Author(s): Miyamoto T
  • Organizer: Korean Society of Bone Metabolism
  • Place of Presentation: Seoul, Korea
  • Year and Date: 20110527-29
• [Presentation] The IRAK4-p38 signal is a differentiation switch for reciprocal formation of osteoclasts and foreign body giant cells (2011)
  • Author(s): Miyamoto H, Morioka H, Chiba K, Toyama Y, Miyamoto T
  • Organizer: 2011 Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Long Beach, California, USA
  • Year and Date: 20110113-16
• [Presentation] 転写抑制因子Blimp1-Bcl6 axisによる破骨細胞分化および骨恒常性制御 (2010)
  • Author(s): 宮本健史
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
  • Year and Date: 20101014-15
• [Presentation] IRAK4-p38シグナルはimplant failureの治療に対する分子標的である (2010)
  • Author(s): 宮本裕也、宮本健史、森岡秀夫、千葉一裕、戸山芳昭
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 京都
  • Year and Date: 20101014-15
• [Presentation] 細胞融合の新たな展開 (2010)
  • Author(s): 宮本健史
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100721-23
• [Presentation] RANKLによる新たな破骨細胞分化機構 (2010)
  • Author(s): 宮本健史
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100721-23
• [Presentation] IRAK4-p38シグナルはimplant failureの治療に対する分子標的である (2010)
  • Author(s): 宮本裕也、戸山芳昭、宮本健史
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100721-23
• [Presentation] Blimp1およびBcl6による破骨細胞分化制御 (2010)
  • Author(s): 宮内芳輝、千葉一裕、戸山芳昭、宮本健史
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100721-23
• [Presentation] ビタミンEは破骨細胞融合を促進し骨量減少を引き起こす (2010)
  • Author(s): 藤田浩二、岩崎牧子、古賀貴子、高柳広、龍谷公隆、玉井浩、新井洋由、宮本健史、伊藤裕、四宮謙一、竹田秀
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 20100721-23
• [Presentation] 細胞融合を標的とした破骨細胞制御機構の解明: DC-STAMPによる破骨細胞制御 (2010)
  • Author(s): 宮本健史
  • Organizer: 第54回日本リウマチ学会
  • Place of Presentation: 兵庫
  • Year and Date: 20100422-25
• [Presentation] 破骨細胞分化を制御する新規因子 (2010)
  • Author(s): 宮本健史
  • Organizer: 第8回"Japan Conference on Bone & Joint Diseases"研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-23
• [Book] Molecules regulating macrophage fusions. Cell Fusions : Regulation and Control (2010)
  • Author(s): Miyamoto T and Suda T
  • Total Pages: 233-248
• [Book] Vitamin D : Biochemistry, Nutrition and Roles(Vitamin D and Bone). Vitamin D : Biochemistry, Nutrition and Roles,-3rd Quarter (2010)
  • Author(s): Sadaoki Sakai, Yoshiteru Miyauchi, Yoshiaki Toyama, Takeshi Miyamoto
  • Total Pages: 105-128