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2012 Fiscal Year Final Research Report

Role of caveolae and caveolinin postconditioning-induced cardiac protection

Research Project

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Project/Area Number 21689042
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Anesthesiology/Resuscitation studies
Research InstitutionThe University of Tokushima

Principal Investigator

TSUTSUMI Yasuo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 講師 (90523499)

Project Period (FY) 2009 – 2012
Keywords麻酔学 / 心筋虚血再灌流障害
Research Abstract

Caveolae are small, flask-like invaginations of the plasma membrane. Caveolins are structural proteins found in caveolae that have scaffolding properties to allow organization of signaling. The authors tested the hypothesis that cardiac protection induced by postconditioning is caveolae or caveolin dependent.

  • Research Products

    (25 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (16 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Differential effects of propofol and isoflurane on glucose utilization and insulin secretion.2011

    • Author(s)
      Katsuya Tanaka, Takashi Kawano, Yasuo Tsutsumi, Michiko Kinoshita, Nami Kakuta, Kayo Hirose, Masakazu Kimura, and Shuzo Oshita
    • Journal Title

      Life Sci

      Volume: 88 Pages: 96-103

    • DOI

      doi:10.1016/j.lfs.2010.10.032.

    • Peer Reviewed
  • [Journal Article] Compound K, a metabolite of ginsenosides, induces cardiac protection mediated nitric oxide via Akt/PI3K pathwa2011

    • Author(s)
      Yasuo Tsutsumi, Rie Tsutsumi, Kazuaki Mawatari, Yutaka Nakaya, Michiko Kinoshita, Katsuya Tanaka, and Shuzo Oshita
    • Journal Title

      Life Sci

      Volume: 88 Pages: 725-729

    • DOI

      doi:10.1016/j.lfs.2011.02.011.

    • Peer Reviewed
  • [Journal Article] Ingrid R. Niesman, Timo Rieg, Volker Vallon, Paul A. Insel, Hemal H. Patel, and David M. RothCardiac-specific overexpression of caveolin-3 attenuates cardiac hypertrophy and increases natriuretic peptide expression and signaling.2011

    • Author(s)
      Yousuke T. Horikawa, Mathivadhani Panneerselvam, Yoshitaka Kawaraguchi, Yasuo Tsutsumi, Sameh S. Ali, Ravi C. Balijepalli, Fiona Murray, Brian P
    • Journal Title

      J Am Coll Cardiol

      Volume: 57 Pages: 2273-2283

    • DOI

      doi:10.1016/j.jacc.2010.12.032.

    • Peer Reviewed
  • [Journal Article] Role of the O-linked β-N-acetylglucosamine in the cardioprotection induced by isoflurane2011

    • Author(s)
      Kayo Hirose, Yasuo Tsutsumi, Rie Tsutsumi, Masayuki Shono, Erika Katayama, Michiko Kinoshita, Katsuya Tanaka, and Shuzo Oshita
    • Journal Title

      Anesthesiology

      Volume: 115 Pages: 955-962

    • DOI

      doi:10.1097/ALN.0b013e31822fcede.

    • Peer Reviewed
  • [Journal Article] Brian P. Head, Piyush M. Patel, David M. Roth, and Hemal H. Patel. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection.2010

    • Author(s)
      Yasuo Tsutsumi, Yoshitaka Kawaraguchi, Yousuke T. Horikawa, Ingrid R. Niesman, Michael W. Kidd, Blake Chin-Lee
    • Journal Title

      Anesthesiology

      Volume: 112 Pages: 1136-1145

    • DOI

      doi:10.1097/ALN.0b013e3181d3d624.

    • Peer Reviewed
  • [Journal Article] Opioid-induced preconditioning is dependent on caveolin-3 expression2010

    • Author(s)
      Yasuo Tsutsumi, Yoshitaka Kawaraguchi, Ingrid R. Niesman, Hemal H. Patel, and David M. Roth
    • Journal Title

      Anesth Analg

      Volume: 111 Pages: 1117-1121

    • DOI

      doi:10.1213/ANE.0b013e3181f3351a.

    • Peer Reviewed
  • [Journal Article] epicatechin-induced cardiac protection is dependent on δ opioid receptor stimulation2010

    • Author(s)
      Mathivadhani Panneerselvam, Yasuo Tsutsumi, Jacqueline A. Bonds, Yousuke T. Horikawa, Michelle Saldana, Nancy D. Dalton, Brian P. Head, Piyush M. Patel, David M. Roth, and Hemal H. Patel
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 299 Pages: H1604-1609

    • DOI

      doi:10.1152/ajpheart.00073.2010

    • Peer Reviewed
  • [Presentation] アミノ酸の mTOR/p70S6K 経路を介した心筋保護作用の影響2012

    • Author(s)
      神邊紀子
    • Organizer
      第59回日本麻酔科学会
    • Place of Presentation
      神戸国際会議場・神戸市
    • Year and Date
      2012-08-06
  • [Presentation] 心筋保護作用における吸入麻酔薬とゲラニルゲラニルアセトンの相互作用-細胞膜マイクロドメインに及ぼす影響2012

    • Author(s)
      堤保夫
    • Organizer
      第59回日本麻酔科学会
    • Place of Presentation
      神戸国際会議場・神戸市
    • Year and Date
      2012-08-06
  • [Presentation] Protective effects of amino acids on the ischemic myocardium via mTOR/S6 kinase pathway2012

    • Author(s)
      Yasuo Tsutsumi
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      San Diego Convention Center, California, USA
    • Year and Date
      2012-04-23
  • [Presentation] The relation between isoflurane-induced O-linkedβ-N-acetylglucosamine and mitochondrial functio2011

    • Author(s)
      Kayo Hirose
    • Organizer
      he American Society of Anesthesiologist Annual Meeting
    • Place of Presentation
      Chicago Convention Center, Illinois, USA
    • Year and Date
      2011-10-16
  • [Presentation] Simvastatin restores anesthetic postconditioning in the presence of hyperglycemia in vivo rabbits2011

    • Author(s)
      Katsuya Tanaka
    • Organizer
      the American Society of Anesthesiologist Annual Meeting
    • Place of Presentation
      Chicago Convention Center, Illinois, USA
    • Year and Date
      2011-10-16
  • [Presentation] 、イソフルランのポストコンディショニング効果における Ca2+依存性 K+チャネルと cAMP 依存性プロテインキナーゼの役割2011

    • Author(s)
      木下倫子
    • Organizer
      第58回日本麻酔科学会
    • Place of Presentation
      神戸国際会議場・神戸市
    • Year and Date
      2011-05-19
  • [Presentation] イソフルランによる心筋保護効果における O-Linked β-N-Acetylglucosamine とミトコンドリア機能2011

    • Author(s)
      廣瀬佳代
    • Organizer
      第58回日本麻酔科学会
    • Place of Presentation
      神戸国際会議場・神戸市
    • Year and Date
      2011-05-19
  • [Presentation] Geranylgeranylacetone induced delayed cardiac preconditioning requires caveolin-32011

    • Author(s)
      Yasuo Tsutsumi
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      Washington D.C. Convention Center, Washington D.C. USA
    • Year and Date
      2011-04-13
  • [Presentation] The role of O-linked β-N-acetylglucosamine in the cardiac protection induced by isoflurane2010

    • Author(s)
      Kayo Hirose
    • Organizer
      the American Society of Anesthesiologist Annual Meeting
    • Place of Presentation
      San Diego Convention Center, California, US
    • Year and Date
      2010-10-16
  • [Presentation] オピオイドプレコンディショニングの細胞膜ドメインに及ぼす影響2010

    • Author(s)
      堤保夫
    • Organizer
      第56回日本麻酔科学会
    • Place of Presentation
      神戸国際会議場・神戸市
    • Year and Date
      2010-08-16
  • [Presentation] イソフルランによる心筋保護効果におけるO-Linkedβ-N-Acetylglucosamine の役割2010

    • Author(s)
      廣瀬佳代
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡国際会議
    • Year and Date
      2010-06-04
  • [Presentation] 吸入麻酔薬による遅延型プレコンディショニングの細胞膜ドメインに及ぼす影響2010

    • Author(s)
      堤保夫
    • Organizer
      第57回日本麻酔科学会
    • Place of Presentation
      福岡国際会議場・福岡市
    • Year and Date
      2010-06-04
  • [Presentation] Role of mTOR/p70S6K in amino acid induced cardiac protection2010

    • Author(s)
      Erika Katayama
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      Anaheim, Convention Center, California, USA.
    • Year and Date
      2010-04-27
  • [Presentation] Inhibition of glycogen synthase kinase-3β is involved in isoflurane-induced delayed cardiac protection2010

    • Author(s)
      Yoshitaka Kawaraguchi
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      Anaheim Convention Center, California, USA.
    • Year and Date
      2010-04-26
  • [Presentation] produces cardiac protection by activating Akt phosphorylation.2010

    • Author(s)
      Rie Tsutsumi, Compound K
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      Anaheim Convention Center, California, US
    • Year and Date
      2010-04-25
  • [Presentation] Role of O-linked β-N-acetylglucosamine in isoflurane induced cardiac protection.2010

    • Author(s)
      Yasuo Tsutsumi
    • Organizer
      Experimental Biology Annual Meeting
    • Place of Presentation
      Anaheim Convention Center, California, USA.
    • Year and Date
      2010-04-25
  • [Book] 大下修造「徹底ガイド 心臓麻酔 Q&A-心臓麻酔における臓器保護-心臓手術中の心筋保護」麻酔科学レクチャー2009

    • Author(s)
      田中克哉、堤保夫、
    • Total Pages
      901-909
    • Publisher
      総合医学社
  • [Remarks]

    • URL

      http://www.tokushima-u.ac.jp/med/culture/masui_totsu/ikyoku/

URL: 

Published: 2014-08-29  

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