2011 Fiscal Year Final Research Report
The EMT and its associated metastatic potential induced by microenvironmental oncogenic stress in refractory ovarian cancer
| Project/Area Number |
21689045
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagoya University |
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Principal Investigator |
KAJIYAMA Hiroaki 名古屋大学, 大学院・医学系研究科, 准教授 (00345886)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 上皮間葉転換(EMT) / 卵巣癌 / 腹膜播種 / 薬剤耐性抗癌剤 / 転写因子 |
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| Research Abstract |
We identified the novel EMT inducible transcriptional factor associated with the metastasis/invasion of ovarian cancer. Of these, ALX-1 and PLAG2positively influenced the formation of peritoneal metastasis. Furthermore, in drug-refractory ovarian cancer model, we clarified the novel mechanism via microRNA(miR-200c) in the link between enhanced metastatic capability and EMT. Furthermore, it was demonstrated that EMT in mesothelial cells, as well as carcinoma cells also play acrucial role in the development of peritoneal dissemination. Our current study suggested the EMT inducible factor targeting therapy may lead to a new approach for the treatment of progression to the peritoneum and drug-resistance of ovarian cancer.
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[Book] Curr Cancer Drug Targets2011
Author(s)
Ino K, Shibata K, Yamamoto E, KajiyamaH, Nawa A, Mabuchi Y, Yagi S, Minami S, Tanizaki Y, Kobayashi A, Kikkawa F.
Total Pages
405-411
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