2010 Fiscal Year Final Research Report
Biological and psychological study on impulsive behavior
| Project/Area Number |
21700290
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cognitive science
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| Research Institution | Kyoto University (2010)
Hiroshima University (2009) |
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Principal Investigator |
NOMURA Michio Kyoto University, 大学院・教育学研究科, 准教授 (60399011)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 衝動性 / 運動制御 / 感情制御 / ドーパミン神経系遺伝子多型 / 前頭前野腹外側部 |
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| Research Abstract |
Brain neuro-imaging studies with concurrent neuro-pharmacological measurement of the effect of gene polymorphisms appear to be useful in clarifying the relationships between personality traits and information processing within distinct brain regions. Catechol-O-methyltransferase (COMT) is involved in functional modulation dopamine neurons and is thus likely to influence frontal-executive functioning. Using functional magnetic resonance imaging (f MRI), we examined whether and how this COMT Val 158 Met gene polymorphism modulates impulsivity-related brain activation by evaluating a Go/No-go task. We found that the COMT Val 158 Met genotypes influence the human prefrontal brain activation and the genotype underlies impulsivity-related motor control appropriate to the affective structure of an environment through reward and penalty information.
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