2010 Fiscal Year Final Research Report
Structural study of hydration water molecules in protein crystals by coupled use of neutron and X-ray structure analysis
| Project/Area Number |
21700329
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Bioinformatics/Life informatics
|
|---|
| Research Institution | Japan Atomic Energy Agency |
|---|
Principal Investigator |
OHHARA Takashi Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究員 (60391249)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | バイオインフォマティックス / 中性子構造解析 |
|---|
| Research Abstract |
The author developed an efficient method to determine the structure of hydration water molecules in protein crystals without arbitrariness by coupled use of single crystal neutron and X-ray structure analysis. In addition, the author successfully clarified the role of hydration water molecules for the anti-freeze activity of an anti-freeze protein by a mutation study and coupled use of neutron and X-ray structure analysis.
|
