2010 Fiscal Year Final Research Report
Structural study of hydration water molecules in protein crystals by coupled use of neutron and X-ray structure analysis
Project/Area Number |
21700329
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Bioinformatics/Life informatics
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Research Institution | Japan Atomic Energy Agency |
Principal Investigator |
OHHARA Takashi Japan Atomic Energy Agency, 量子ビーム応用研究部門, 研究員 (60391249)
|
Project Period (FY) |
2009 – 2010
|
Keywords | バイオインフォマティックス / 中性子構造解析 |
Research Abstract |
The author developed an efficient method to determine the structure of hydration water molecules in protein crystals without arbitrariness by coupled use of single crystal neutron and X-ray structure analysis. In addition, the author successfully clarified the role of hydration water molecules for the anti-freeze activity of an anti-freeze protein by a mutation study and coupled use of neutron and X-ray structure analysis.
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Research Products
(18 results)