2011 Fiscal Year Final Research Report
Molecular diversity and function of Longitudinals lacking transcription factors in regulating courtship behavior in Drosophila
| Project/Area Number |
21700338
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tohoku University |
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Principal Investigator |
SATO Kosei 東北大学, 国際高等研究教育機構, 助教 (40451611)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 行動神経科学 / 神経発生 |
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| Research Abstract |
Our results suggest the longitudinal lacking (lola)gene, encoding putative transcription factors of the BTB-Zn-finger family, plays an essential role to generate the sexual differences in neuronal structures and behavior by producing sexually dimorphic transcription factors. In males, Lola acts as a transcriptional cofactor of Fru, the male-specific sex determination factor that masculinizes subsets of neurons that govern courtship behavior. In females, Lola controls female-specific neurite formation in a fru-independent manner. Collectively, lola might acquire its ability to orchestrate sexual development of the entire brain by producing hundreds of Lola isoforms each with potentially different target specificity.
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[Presentation] longitudinals lacking cooperates with fruitless to generate sexual differences in neuronal structures and behavior2010
Author(s)
Sato, K., Toba, G., Ito, H., Koganezawa, M. and Yamamoto, D.
Organizer
Everything you ever wanted to know about sex
Place of Presentation
workshop, Chicago, U. S. A.
Year and Date
2010-03-10
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