2010 Fiscal Year Final Research Report
Functional roles of Lipid signaling in the neuronal network formation
| Project/Area Number |
21700339
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Tsukuba |
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Principal Investigator |
HASEGAWA Hiroshi University of Tsukuba, 大学院・人間総合科学研究科, 助教 (10332230)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 細胞内脂質 / 神経細胞 / ホスファチジルイノシトール4-リン酸5-キナーゼ / ホスファチジルエタノールアミン |
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| Research Abstract |
1) We developed the knockout mice of two isozymes of phosphatidylinositol 4-phosphate 5-kinases (PIP5K_A and PIP5K_B), which are phospholipid metabolizing enzymes to synthesize phosphatidylinositol 4,5-bisphosphate (PIP_2). From the analyses of these knockout mice, we found that PIP5K_A and PIP5K_B are crucial for spermatogenesis. 2) We also found that phosphatidylethanolamine and its synthetic enzyme, ethanolamine kinase-1, play an important role in neurite elongation.
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Research Products
(35 results)
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[Journal Article] Sequential Regulation of DOCK2 dynamics by two phospholipid during neurtrophil2009
Author(s)
Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA, Fukui Y
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Journal Title
Science 324
Pages: 384-387
Peer Reviewed
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