2011 Fiscal Year Final Research Report
Development of motor functions by formation of local neural circuits
| Project/Area Number |
21700344
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOHSAKA Hiroshi 東京大学, 大学院・理学系研究科, 助教 (20431900)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 発生・発達・再生神経科学 / 神経回路 |
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| Research Abstract |
Network of neurons generates variety of animal's activities such as moving, sensing and memorizing. While the properties of each neuron have been deeply examined, how assembly of neurons creates coherent and coordinated functions remains to be clarified. In this study, we dissected Drosophila larval motor circuits that generate spatiotemporal patterns of locomotion. We succeeded in identification of a group of interneurons(we named them "PMSI") which control the speed of the larval locomotion. By detailed analysis of PMSI using Ca imaging and optogenetics, we revealed some of the mechanisms how motor circuits regulate speed of locomotion.
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