2010 Fiscal Year Final Research Report
Analysis of the molecular mechanism regulating synaptic functions in the mouse cerebellar cortex using a system for conditional knockout in the cells constituting synapses.
| Project/Area Number |
21700348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Niigata University |
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Principal Investigator |
ABE Manabu Niigata University, 脳研究所, 助教 (10334674)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 分子・細胞神経科学 / グルタミン酸受容体 |
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| Research Abstract |
The aim of this study was to reveal the relationship between molecular dynamics of glutamate receptor complex and regulation of synaptic function in cerebellar cortex. We first developed a system for conditional knockout in the cells constituting synapses. By analyzing the cell type-selective knockout mice, we found that the activity of glutamate receptors in Purkinje cells may regulate the presynaptic function at climbing and parallel fiber synapses and that β-catenin expressed in Bergmann glia may play an indispensable role in the formation of the laminar structure of cerebellum.
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