2011 Fiscal Year Final Research Report
Construction of a computational model for gait disorder using neuronal oscillators controlled by the cortico-basal ganglia loop
| Project/Area Number |
21700353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 計算論的神経科学 / 歩行モデル / 歩行障害 / パーキンソン病 |
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| Research Abstract |
In this study, we developed a computational model of human gait based on the cortico-basal ganglia loop circuit. The model reproduced gait patterns of normal subjects and patients with Parkinson' s disease(PD). First, we calculated quantitative indices on gait patterns, and characterized the differences between young healthy subjects and elderly healthy subjects and between elderly healthy subjects and elderly PD patients. Second, we constructed the computational model consisting of the cortico-basal ganglia loop and neuronal oscillators. The computer simulation using this model reproduced the gait motion of the legs of elderly healthy subjects and elderly PD patients, respectively. We confirmed that the cortico-basal ganglia loop could change the gait control.
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[Journal Article] Spectral analysis of field potential recordings by DBS electrode for localization of subthalamic nucleus in patients with Parkinson' s disease2009
Author(s)
Yasushi Miyagi, Tsuyoshi Okamoto, Takato Morioka, Shozo Tobimatsu, Yoshitaka Nakanishi, Kazuyuki Aihara, Kimiaki Hashiguchi, Nobuya Murakami, Fumiaki Yoshida, Kazuhiro Samura, Shinji Nagata, Tomio Sasaki
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Journal Title
Stereotactic and Functional Neurosurgery
Volume: 87
Pages: 211-218
Peer Reviewed
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