2011 Fiscal Year Final Research Report
Molecular mechanisms underlying COUP-TFI/II-mediated temporal identity transition of neural stem cells
| Project/Area Number |
21700357
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The Institute of Physical and Chemical Research (2011)
Keio University (2009-2010) |
|---|
Principal Investigator |
KANEDA Hayato 独立行政法人理化学研究所, 免疫転写制御研究グループ, 上級研究員 (40528212)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | グリア / 再生医学 / 時間特異性 / 神経幹細胞 / 神経発生 / 神経科学 / 脳・神経 |
|---|
| Research Abstract |
I succeeded in identification of the downstream effector of COUP-TFs and elucidation of the major molecular mechanisms underlying the neurogenic-to-gliogenic transition of developing neural stem cells. Furthermore, control of the effector enabled us to control the neural stem cell competence bi-directionally, neurogenic or gliogenic. These findings will greatly contribute to the clinical applications of neural stem cells for the treatment of CNS injury and disease.
|
