2010 Fiscal Year Final Research Report
RNA-binding protein Musashi1-mediated miRNA regulation
| Project/Area Number |
21700358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Keio University |
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Principal Investigator |
KAWAHARA Hironori Keio University, 医学部, 助教 (00424177)
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| Project Period (FY) |
2009 – 2010
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| Keywords | Musashi1 / let-7 / Lin28 / 幹細胞 / ES細胞 |
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| Research Abstract |
Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural stem/progenitor cells (NS/PCs) as well as in other tissue stem cells. I showed that Msi1 works in concert with Lin28 to regulate post-transcriptional miRNA biogenesis in the cropping step, which occurs in the nucleus. Also, I found that Msi1 enhanced the localization of Lin28 to the nucleus and also inhibited the nuclear cropping step of another let-7 family miRNA, miR98.
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