2011 Fiscal Year Final Research Report
The importance of myelin in the regulation of axonal mitochondria
| Project/Area Number |
21700361
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 髄鞘(ミエリン) / オリゴデンドロサイト / ミトコンドリア / 軸索 |
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| Research Abstract |
Vertebrate myelinated axons propagate electrical impulse rapidly by salutatory conduction. Paranodal axo-glial junctions play a crucial role in the organization and maintenance of molecular domains in myelinated axons. Cerebroside sulfotransferase(CST) deficient mice show disruption of the paranodal axo-glial junction both in the CNS and the PNS. We reported that axonal mitochondria at the nodes of Ranvier were large and swollen, and that axonal transport related protein levels decreased in the PNS of CST-deficient mice. We also found that the finding of frequent focal axonal swellings in the cerebellar Purkinje neurons.
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