2010 Fiscal Year Final Research Report
Functional analysis of NF-Y transcription factor in nervous system
| Project/Area Number |
21700373
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
YAMANAKA Tomoyuki The Institute of Physical and Chemical Research, 構造神経病理研究チーム, 研究員 (00381575)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 転写印紙 / NF-Y / 神経細胞 / ノックアウトマウス / 神経変性 |
|---|
| Research Abstract |
To investigate physiological function of NF-Y transcription factor in nervous system, we made neuron-specific NF-YA (one of NF-Y components) conditional knockout mice. Although the knockout mice could be born, increase in body weight was severely affected, resulting in neonatal death. We further identified many potential NF-Y target genes involved in gene transcription/translation and protein folding/degradation by ChIP on CHIP analysis using mouse brain. Thus, NF-Y-mediated expression of these genes in neuron may be important for neonatal mouse development.
|
