2010 Fiscal Year Final Research Report
Regeneration of hippocampal cells by recruitment of endogenous progenitors with deep brain stimulation
| Project/Area Number |
21700379
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | University of Toyama |
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Principal Investigator |
SUGIMORI Michiya University of Toyama, 大学院・医学薬学研究部(医学), 助教 (20464026)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経再生 / 神経可塑性 / 神経幹細胞 |
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| Research Abstract |
The adult central nervous system is extremely vulnerable to injuries and diseases, and has difficulty repairing itself. The discoveries of endogenous neural stem/progenitor cells in the adult brain raise the possibility of repairing injured tissue and of promoting recovery in brain function with manipulating and recruitment of the progenitors. However, there are no well-established methods to manipulate and/or recruit endogenous progenitors in vivo. Here we addressed the possibility of whether endogenous progenitors can be recruited by manipulating neural activity with deep brain stimulation. When we electrically stimulated the rat perforant path with high frequency stimulation (HFS) to induce long-term plasticity in the dentate gyrus, a well-known neurogenic region in the adult brain, we found an increase in the number of BrdU incorporated cells after HFS, indicating that neural progenitor proliferation was enhanced with HFS. We also found an increase in the number of clones of neural progenitors, which corresponds to the neural stem/progenitor cell activation. Thus, we conclude that HFS enhanced neural progenitor activation and proliferation. Our results suggest the possibilities for deep brain stimulation becoming a cell regeneration therapy for neurological diseases.
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