2010 Fiscal Year Final Research Report
Mechanism of compensatory neural network formation after brain injury
| Project/Area Number |
21700381
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Osaka University |
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Principal Investigator |
UENO Masaki Osaka University, 大学院・医学系研究科, 助教 (40435631)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 大脳損傷 / 神経回路 / 可塑性 / 皮質脊髄路 / 運動機能 / 自然回復 |
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| Research Abstract |
Brain injury that results in an initial behavioral deficit is frequently followed by spontaneous functional recovery. In the present study, we showed that reorganization of the remnant neural network was crucial for spontaneous recovery of motor function following brain injury in mice. Furthermore, we identified several key signals (BDNF-TrkB, GABA, EphA4-EphrinB3, MAG/Nogo/OMgp-PirB) that modify this new network formation.
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[Journal Article] Olfactory mucosa transplantation following spinal cord injury improves voiding efficiency by suppressing detrusor sphincter dyssynergia in rats.2010
Author(s)
Nakayama J, Takao T, Kiuchi H, Yamamoto K, Fukuhara S, MiyagawaY, Aoki M, Iwatsuki K, Yoshimine T, Ueno M, Yamashita T, Nonomura N, Tsujimura A, Okuyama A.
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Journal Title
J Urol. 184(2)
Pages: 775-782
Peer Reviewed
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