2010 Fiscal Year Final Research Report
Analysis plasticity of monoaminergic and cholinergic neurons in nalcoleptic mice
| Project/Area Number |
21700401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経疾患の病態と治療 / 神経ペプチド / 睡眠障害 |
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| Research Abstract |
I examined monoaminergic neuronal activities of narcoleptic mice (orexin neuron deficiency mice). Firing frequency of Locus ceruleus noradrenergic neuron was increased in narcoleptic mice by in vivo extracellular recording during wakefulness and slow wave sleep. In vitro patch clamp recording, IPSC of noradrenergic neuron was reduced in narcoleptic mice. This reduction might be results the increasing of firing frequency of noradrenergic neuron in narcoleptic mice.
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[Journal Article] Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory2011
Author(s)
Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, YamamotoM, Yanagisawa M, Sakurai T
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Journal Title
PLoS One
Volume: 6(2)
Pages: e16972
Peer Reviewed
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[Journal Article] Thrombin activates Ca^<2+>-permiating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells2011
Author(s)
Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M
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Journal Title
Shinshu Medical Journal
Volume: 59(1)
Pages: 13-26
Peer Reviewed
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