2010 Fiscal Year Final Research Report
Physiological analysis of synaptic tagging
| Project/Area Number |
21700405
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
ISHIKAWA Yasuyuki Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (90346320)
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| Project Period (FY) |
2009 – 2010
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| Keywords | シナプス可塑性 / 連合記憶 / ニューロプシン / シナプス・タグ |
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| Research Abstract |
Activity-dependent synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. Synaptic tagging and capture could be involved in activity-dependent synaptic plasticity, because it distinguishes between local mechanisms of synaptic tags and cell-wide mechanisms that are responsible for the synthesis of plasticity-related proteins. I found that a plasticity related serine protease, neuropsin, is involved in the tag-setting process during LTP at basal and apical dendritic inputs. Neuropsin is involved in synaptic tagging and cross-tagging during LTP at apical dendritic inputs via integrin beta-1 and CaMKII signaling.
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[Journal Article] Timp-3 deficiency impairs cognitive function in mice.2009
Author(s)
Baba Y, Yasuda O, Takemura Y, Ishikawa Y, Ohishi M, Iwanami J, Mogi M, Doe N, Horiuchi M, Maeda N, Fukuo K, Rakugi H.
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Journal Title
Lab Invest. 89
Pages: 1340-7
Peer Reviewed
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