2010 Fiscal Year Final Research Report
Elucidation of the role of calpain on the degeneration of spines caused by diabetes using a low molecular weight compound
| Project/Area Number |
21700414
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
KOSUGE Yasuhiro Nihon University, 薬学部, 助教 (70383726)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Keywords | 糖尿病 / 海馬 / スパイン / カルパイン / シナプス可塑性 |
|---|
| Research Abstract |
Chronic hyperglycemia, such as diabetes mellitus, has been shown to induce cognitive impairment and defects of long-term potentiation in the hippocampus. In order to assess the mechanism of cognitive impairment by hyperglycemia, the expression of post-synaptic density 95 (PSD-95), a key components of spine, was investigated in a human neruoblastoma cell line, SH-SY5Y, after exposure to high-glucose and in the hippocampus in streptozotocin-induced diabetic mice. These results suggest that decrease in phosphorylated ERK plays a significant role in the adverse effect of chronic hyperglycemia in vivo and in vitro.
|
