2010 Fiscal Year Final Research Report
The role of molecular diversity of milton gene for the maintenance of neuronal axon
| Project/Area Number |
21700424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Shinshu University |
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Principal Investigator |
YONEKURA Shinichi Shinshu University, 農学部, 助教 (40443113)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 神経科学 / 軸索 / スプライシング |
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| Research Abstract |
Point mutation of different alternative splicing axon of milton gene, required for the anterograde transport of mitochondria, indicated the different phenotype such as axon degeneration or abnormal neurite outgrowth. Expressing single milton isoforms was sufficient to rescue the mutant phenotype. This result indicated that multiple isoforms were anticipated in the maintenance of neuronal axon. Although both mutant neurons failed to target mitochondria to their terminals, abnormal mitochondria transport was not sufficient to cause axon degeneration.
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