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2010 Fiscal Year Final Research Report

RoIes of feed-forward inhibition in auditory coincidence detection

Research Project

  • PDF
Project/Area Number 21700431
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionKyoto University

Principal Investigator

YAMADA Rei  京都大学, 医学研究科, 助教 (70422970)

Project Period (FY) 2009 – 2010
Keywords同時検出 / 生理学 / 神経科学 / 聴覚 / 音源定位
Research Abstract

Neurons in nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs and process interaural time differences (ITDs) for sound localization. In this study, we found a feed-forward inhibition that follows the EPSCs from ipsilateral cochlear nucleus after a short time delay (1-2 ms). These IPSCs were observed in the low frequency NL neurons and likely mediated by GABA-positive interneurons, which distributed in and near the low frequency NL region. Model simulations demonstrate that phasic IPSCs narrowed a time window of coincidence detection and increased the ITD sensitivity during a low-level of excitatory inputs. We concluded that the complementary interaction between the feed-forward and feedback inhibitions effectively increased the ITD sensitivity over a wide range of sound levels in low frequency NL neurons.

  • Research Products

    (9 results)

All 2011 2010 2009 Other

All Presentation (6 results) Book (1 results) Remarks (2 results)

  • [Presentation] トリ層状核神経細胞での両耳間時差検出に対する二つの抑制機構の相補的な働き2010

    • Author(s)
      山田 玲、奥田裕子、西野恵里、久場博司、石井孝広、大森治紀
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
  • [Presentation] 微小両耳間時間差検出の音圧依存的調節における上オリーブ核の作用2010

    • Author(s)
      西野恵里、山田 玲、久場博司、大森治紀
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-19
  • [Presentation] Precisely timed inhibition for processing interaural time differencecue at low frequency in the nucleus laminaris of birds2009

    • Author(s)
      Rei Yamada, Hiroko Okuda, Eri Nishino, Hiroshi Kuba, Takahiro Ishii, Harunori Ohmori
    • Organizer
      39th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2009-10-18
  • [Presentation] トリ層状核の両耳間時間差検出における両耳間音圧差の作用2009

    • Author(s)
      西野恵里、山田 玲、久場博司、大森治紀
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
  • [Presentation] 鳥類層状核神経細胞における聴覚同時検出に対する位相情報を保持した抑制入力の働き2009

    • Author(s)
      山田 玲、奥田裕子、西野恵里、久場博司、石井孝広、大森治紀
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
  • [Presentation] Roles of phase-locked inhibition for processing interaural time difference cue in the nucleus laminaris of birds2009

    • Author(s)
      Rei Yamada, Hiroko Okuda, Eri Nishino, Hiroshi Kuba, Takahiro Ishii, Harunori Ohmori
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2009-07-28
  • [Book] Chapter 27 "Frequency dependent specialization for processing binaural auditory cues in avian sound localization circuits." in "Advances in Sound Localization"2011

    • Author(s)
      Rei Yamada, Harunori Ohmori
    • Publisher
      Intech
  • [Remarks]

    • URL

      http://www.med.kyoto-u.ac.jp/J/grad_school/introduction/1603/

  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/medical/1710/1712/saibouseirigaku_bunshidoutaigaku.html

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Published: 2013-07-31  

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