2010 Fiscal Year Final Research Report
Identification of modifier loci for type 1 diabetes in the KDP rat
| Project/Area Number |
21700449
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Kobe University |
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Principal Investigator |
YOKOI Norihide Kobe University, 大学院・医学研究科, 特命准教授 (70311610)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 遺伝学 / 遺伝子 / 糖尿病 / 動物モデル / ラット |
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| Research Abstract |
To identify modifier genes for type 1 diabetes in the Komeda diabetes-prone (KDP) rat, we performed genetic analysis using progeny produced from two different crosses. Genetic analysis of these two crosses revealed that modifier genes are located on several chromosomal regions, and that some of them showed age-or sex-specific effects. A whole picture of the genetic loci for type 1 diabetes in the KDP rat was clarified.
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