2010 Fiscal Year Final Research Report
Generation of Diabetic model mouse using improved toxin receptor
| Project/Area Number |
21700450
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
SAITO Michiko Nara Institute of Science and Technology, バイオサイエンス研究科, 助教 (40379558)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 疾患モデル / 糖尿病 / 毒素受容体 |
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| Research Abstract |
Previously we generated the diabetic model mouse by using TRECK method. This model mouse can be determined when to develop diabetes by the administration of Diphtheria toxin (DT). We can also control the level of the symptom. However, the transgenic mouse displayed abnormality in glucose tolerance and islet structure even without DT treatment. In this study, to solve these problems found in the model mouse, we generated improved TRECK diabetic model mice using a modified DT receptor. The new diabetic model mice showed normal architecture of pancreatic islets before DT treatment and they developed hyperglycemia after DT administration.
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