2010 Fiscal Year Final Research Report
Analysis of the infection mechanism of human hepatitis B virus using bio-nanocapsule.
| Project/Area Number |
21700466
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUZAKI Takashi Osaka University, 産業科学研究所, 特任助教(常勤) (90456939)
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| Project Period (FY) |
2009 – 2010
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| Keywords | ナノバイオロジー / ナノメディスン |
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| Research Abstract |
By using novel yeast-derived HBsAg L particles, named bio-nanocapsules (BNC), as noninfectious subviral particles, we studied the infectious mechanisms, especially the membrane fusion mechanism that remain unsolved, of HBV. We successfully identified a novel membrane fusion motif located at the N-terminal region of HBsAg L protein. We also demonstrated that the hydrophobic phenylalanine residues (Phe13 and Phe14) were essential for this fusion activity.
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