2010 Fiscal Year Final Research Report
Diagnostic technique for the detection of colon adenoma using fluorescence lifetime imaging targeting epithelial intracellular molecules
| Project/Area Number |
21700469
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YAMAOKA Yoshihisa Kyoto Prefectural University of Medicine, 医学研究科, 助教 (80405274)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 蛍光寿命 / 腫瘍診断 / 内視鏡 / 自家蛍光 / 大腸上皮細胞 |
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| Research Abstract |
We demonstrated autofluorescence lifetime imaging of human colon specimens obtained by endoscopic mucosal resection (EMR). As a result, we found that there is a difference of fluorescence lifetime using the excitation and fluorescence wavelengths of FAD (flavin adenine dinucleotide) between normal and adenoma regions. This difference is mainly caused by fluorescence from mucosal epithelial intracellular molecules. Autofluorescence lifetime imaging would be a promising and practical method having potential for the detection of colon adenoma targeting intracellular environments.
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