2010 Fiscal Year Final Research Report
Development of Multi-layered nano-device for mitochondrial drug delivery and an innovative approach for mitochondrial disease' therapy
| Project/Area Number |
21700483
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hokkaido University |
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Principal Investigator |
YAMADA Yuma Hokkaido University, 大学院・薬学研究院, 助教 (60451431)
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| Project Period (FY) |
2009 – 2010
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| Keywords | 薬学 / ミトコンドリア / バイオテクノロジー / 癌 / 細胞・組織 |
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| Research Abstract |
Mitochondrial dysfunction is associated with a variety of human diseases. Effective medical therapies for mitochondrial diseases will ultimately require an optimal drug delivery system, which will likely be achieved through innovations in the nanotechnology of intracellular trafficking. To achieve efficient mitochondrial drug delivery, two independent processes, i.e., "cytoplasmic delivery through the cell membrane" and "mitochondrial delivery through the mitochondrial membrane" are required. Here, we report the development of a Dual Function MITO-Porter (DF-MITO-Porter), a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery. We show that the DF-MITO-Porter effectively delivers exogenous macro-biomolecules into the mitochondrial matrix, and provide a demonstration of its potential use in therapies aimed at mitochondrial DNA.
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