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2011 Fiscal Year Final Research Report

Development of 3D-fibrous scaffolds with ability of stimulating mesenchymal stem cells

Research Project

  • PDF
Project/Area Number 21700487
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionNagoya Institute of Technology

Principal Investigator

AKIKO Obata  名古屋工業大学, 大学院・工学研究科, 助教 (40402656)

Research Collaborator NAKAMURA Jin  名古屋工業大学, 大学院・工学研究科, 博士後期課程二年
Project Period (FY) 2009 – 2011
Keywords生体材料 / 組織工学 / ハイブリッド材料 / 細胞培養
Research Abstract

Novel fibrous materials with three dimensional structure were developed for use in the tissue engineering field. Ceramic particles releasing silicate ions, which have been reported to stimulate cell functions, were combined with biodegradable polymer to prepare fibrous materials enhancing cell proliferation and mineralization. The prepared fibrous materials showed flexibility and elasticity. Results of cell culture tests for the materials showed osteoblast-like cells proliferated inside of the fibrous structure of the materials.

  • Research Products

    (21 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (11 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Fabrication of silicate and calcium ion releasable biomaterials with siloxane-containing vaterite2012

    • Author(s)
      Jin Nakamura, Akiko Obata, Toshihiro Kasuga, Julian R Jones
    • Journal Title

      Key Eng. Mater.

      Pages: 493-494, 561-565

    • Peer Reviewed
  • [Journal Article] Electrospun Microfiber Meshes of Silicon-doped Vaterite/Poly(lactic acid) Hybrid for Guided Bone Regeneration2010

    • Author(s)
      Akiko Obata, Toshiki Hotta, Takashi Wakita
    • Journal Title

      Yoshio Ota and Toshihiro Kasuga Acta Biomaterialia

      Volume: 6 Pages: 1248-1257

    • Peer Reviewed
  • [Journal Article] Preparation of Silicon-Containing Poly(lactic acid)-Vaterite Hybrid Membranes2010

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota and Toshihiro Kasuga
    • Journal Title

      Mater. Sci. Forum

      Pages: 638-642, 670-674

    • Peer Reviewed
  • [Journal Article] Electrospun Fibrous Membranes Based on Poly(lactic acid) for Guided Bone Regeneration2009

    • Author(s)
      Akiko Obata, Takashi Wakita, Yoshio Ota and Toshihiro Kasuga
    • Journal Title

      Proc. 22th Inter. Symp. Ceramics in Medicine

      Pages: 579-582

    • Peer Reviewed
  • [Journal Article] Enhanced in vitro Cell Activity on Silicon-Doped Vaterite/Poly(lactic acid) Composites2009

    • Author(s)
      Akiko Obata, Shingo Tokuda and Toshihiro Kasuga
    • Journal Title

      Acta Biomaterialia

      Volume: 5 Pages: 57-62

    • Peer Reviewed
  • [Journal Article] Stimulation of Human Mesenchymal Stem Cells and Osteoblasts Activities in vitro on Silicon-Releasable Scaffolds2009

    • Author(s)
      Akiko Obata and Toshihiro Kasuga
    • Journal Title

      Journal of Biomedical Materials Research

      Volume: 91A Pages: 11-17

    • Peer Reviewed
  • [Journal Article] Preparation of electrospun poly(lactic acid)-based hybrids containing siloxane-doped vaterite particles for bone regeneration

    • Author(s)
      Kie Fujikura, Akiko Obata, Sen Lin, Julian R Jones, Robert V Law, Toshihiro Kasuga
    • Journal Title

      Journal of Biomaterials Science : Polymer Edition

      Volume: (In press)

    • Peer Reviewed
  • [Presentation] 溶出ケイ酸イオンによる骨芽細胞への影響2012

    • Author(s)
      小幡亜希子、中村仁、前田浩孝、春日敏宏、Julian R. Jones
    • Organizer
      日本金属学2012年春期大会
    • Place of Presentation
      横浜
    • Year and Date
      20120328-30
  • [Presentation] Effects of silicate and calcium ions on osteoblast functions2011

    • Author(s)
      Akiko Obata, Jin Nakamura, Hirotaka Maeda, Julian R. Jones, Toshihiro Kasuga
    • Organizer
      2^<nd> German-Japanese Seminar on Advanced Ceramic Materials
    • Place of Presentation
      Erlangen, Germany
    • Year and Date
      20111124-25
  • [Presentation] Preparation of fibrous scaffolds containing calcium and silicon species2011

    • Author(s)
      Akiko Obata, Hiroki Ozasa, Julian R Jones, Toshihiro Kasuga
    • Organizer
      23^<rd> Symposium and Annual Meeting of International Society for Ceramics in Medicine(ISCM)
    • Place of Presentation
      Istanbul, Turkey
    • Year and Date
      20111106-09
  • [Presentation] 生分解性ポリマー・炭酸カルシウムの複合化による骨再建用材料の創製2011

    • Author(s)
      小幡亜希子、春日敏宏
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Year and Date
      20110928-30
  • [Presentation] 骨芽細胞様細胞に対する溶出シリコンの影響2011

    • Author(s)
      小幡亜希子、春日敏宏
    • Organizer
      日本セラミックス協会第24回秋季シンポジゥム
    • Place of Presentation
      札幌
    • Year and Date
      20110907-09
  • [Presentation] 硬組織再建用バイオマテリアルの開発2011

    • Author(s)
      小幡亜希子
    • Organizer
      名工大一自然科学研究機構合同講演会第3回講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
  • [Presentation] カルシウム・シリコン徐放機能を付与した生分解性無機・有機複合体の作製2010

    • Author(s)
      小幡亜希子、春日敏宏、Julian R Jones
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      広島(グランドプリンスホテル広島)
    • Year and Date
      20101129-30
  • [Presentation] Calcium Carbonate/Polymer Composites Releasing Silicon and Calcium Species for Biomaterials2010

    • Author(s)
      Akiko Obata, Shinya Yamada, Julian R. Jones, Toshihiro Kasuga
    • Organizer
      The 27^<th> International Korea-Japan Seminar on Ceramics
    • Place of Presentation
      Incheon, Korea
    • Year and Date
      20101124-26
  • [Presentation] Preparation of Scaffold Materials Releasing Silicon and Calcium Ions for Bone Reconstruction2010

    • Author(s)
      Akiko Obata, Shinya Yamada, Toshihiro Kasuga, Julian R. Jones
    • Organizer
      3^<rd> International Congress on Ceramics(ICC3)
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20101114-18
  • [Presentation] Preparation of Poly(lactic acid)-based Fibrous Membranes Releasing Silicon Species by Electrospinning2010

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R. Jones
    • Organizer
      ESB 2010(23^<rd> European Conference on Biomaterials)
    • Place of Presentation
      Tampere, Finland
    • Year and Date
      20100911-15
  • [Presentation] Poly(lactic acid)-based Fibrous Membranes Releasing Silicon Species2010

    • Author(s)
      Akiko Obata, Toshihiro Kasuga, Julian R. Jones
    • Organizer
      TERMIS-EU 2010, Galway, Ireland
    • Place of Presentation
      Galway, Ireland
    • Year and Date
      20100613-17
  • [Book] Nova Science Publishers Lactic Acid Production, Properties and Health Effects ; Siloxane-Containing Vaterite/Poly(lactic acid) Fibremats with Improved Ductility

    • Author(s)
      Akiko Obata, Toshihiro Kasuga
    • Publisher
      Nova Science Publishers Lactic Acid(in press)
  • [Patent(Industrial Property Rights)] 骨欠損部充填材料およびその製造方法2010

    • Inventor(s)
      春日敏宏、小笹弘貴、小幡亜希子
    • Industrial Property Rights Holder
      名古屋工業大学
    • Industrial Property Number
      特願、2010-80139
    • Filing Date
      2010-03-31
  • [Patent(Industrial Property Rights)] 骨再生誘導膜およびその製造方法2009

    • Inventor(s)
      春日敏宏、小幡亜希子、藤倉喜恵
    • Industrial Property Rights Holder
      名古屋工業大学
    • Industrial Property Number
      特願、2009-208922
    • Filing Date
      2009-09-10

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Published: 2013-07-31  

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