2010 Fiscal Year Final Research Report
Development of Intelligent Biogelators Possessing Collagen Specificity
| Project/Area Number |
21700490
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
MATSUSAKI Michiya Osaka University, 工学研究科, 助教 (00419467)
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| Project Period (FY) |
2009 – 2010
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| Keywords | バイオマテリアル / 高分子化学 / インテリジェント材料 / 再生医学 / ナノバイオ |
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| Research Abstract |
Purpose of this study is the development of collagen specific intelligent biogelators focused on weak intermolecular interaction during triple-helix formation of collagen fibers. We synthesized multi-armed poly(ethylene glycol)s terminally conjugated with collagen peptides and confirmed supramolecular nanoparticle formation of these compounds. Furthermore, these supramolecular nanoparticles specifically crosslinked fibrous collagens. We also confirmed the effect of the nanoparticles on bullous keratopathy rabbit models. Accordingly, the supramolecular nanoparticles would be useful as a collagen specific biogelator in tissue engineering field.
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Research Products
(11 results)
